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Across all doses, pharmacokinetic analyses revealed that peak plasma levels were generally reached within the first few minutes after dosing and the drug exhibited good dose proportionality. Many migraine sufferers who do take triptans have an insufficient therapeutic response to these medications.

Following an initial period of vigorous activity, the mice adopt a characteristic immobile posture and no longer attempt to escape. We used a behavioral model of immobility first postulated by Porsolt and Porsolt et al.

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